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COVID-19 Oral Antiviral Toolkit

This toolkit was last updated 9/14/2022 and is no longer being reviewed for accuracy and updates. Resources should be used with caution, as content may be outdated.

SIDP has developed a COVID-19 Oral Antiviral Toolkit in conjunction with National Alliance of State Pharmacy Associations (NASPA).  The content of this toolkit is informed by the experiences of pharmacists with expertise in the treatment and prevention of COVID-19 and who practice in diverse settings (community, outpatient, inpatient) and diverse patient populations (pediatrics, adults, immunocompromised).

Toolkit Features:

  • Decision tree to assist screening patient eligibility for oral antiviral treatment of COVID-19 in the outpatient setting
  • Process resources (e.g. ordersets, documentation forms) to assist with ordering/prescribing of oral antivirals
  • Educational resources (e.g. handout for pharmacists, product comparison table)
  • Checklist to assist with implementing a COVID-19 Test-to-Treat program at a local institution/facility

SIDP member, Sohail Azam, PharmD (left) with a physician colleague

Toolkit Contents

Outpatient COVID-19 Oral Antiviral Decision Tree

Tool to screen an individual patient's eligibility for oral antiviral therapy to treat mild-to-moderate COVID-19 in the outpatient setting. Available as:

  • PDF version
    • Includes Appendix A - Pharmacist Prescription Procedure for Nirmatrelvir/Ritonavir (Paxlovid) as a fillable form for state-licensed pharmacists in the United States to document prescribing requirements

Educational Resources 

Oral Antiviral Therapy Review for COVID-19 as video presentation and slide handout

Frequently Asked Questions about COVID-19 Oral Antivirals for Pharmacists 

Oral Antiviral Product Comparison Table

Example Order Sets and Forms

Nirmatrelvir/Ritonavir Order Forms

Molnupiravir Order Forms

Test-to-Treat Checklist

Checklist to develop a Test-to-Treat program for COVID-19 at a local institution/facility 

Excerpt from Outpatient COVID-19 Oral Antiviral Therapy Decision Tree

COVID-19 Oral Antiviral Product Comparison Table

Register to Access Toolkit Resources

Sign-up as a Registered Resource User of this free content in order to access toolkit materials and be alerted by SIDP as new revisions/updates emerge. Of note, this content is publicly available at no cost. SIDP membership is not required to register as a toolkit user.

SIDP will not share any contact information provided with any third party and

will only contact registered resource users with information pertaining to educational resources

Once you have signed up as a Registered Resource User, access the toolkit resources using the link below!

Note, SIDP members can also access the toolkit at the link below.


Please keep in mind that information, data, and availability of oral antivirals in COVID-19 is constantly evolving. Use of SIDP guidelines and/or toolkits are intended as recommendations. Use does not supersede clinical judgement based on the assessment of an individual patient by an individual practitioner. The recommendations reflect the best available evidence at the time of publication and are not the sole resource for patient care management and/or an exclusive source of action.

SIDP COVID-19 Oral Antiviral Toolkit Taskforce Members

Special thanks to the following SIDP members for volunteering their time and efforts to the development of this toolkit:

  • Julie Ann Justo
  • Regina Orbach
  • Bryan Alexander
  • Susan Egbert
  • Sohail Azam
  • Akshith Dass
  • Hita Bhagat
  • Michael Klepser

SIDP member, Regina Orbach, PharmD (right), discussing COVID-19 oral antivirals with a pharmacy post-graduate trainee (left)

This toolkit was sponsored by an unrestricted medical grant from Merck.

Release Date: 9/14/2022

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